The Effects of Fatty Acids and Their Monoesters on the Metabolic Activity of Dental Plaque

J Dent Res. 1984 Jan;63(1):2-5. doi: 10.1177/00220345840630010301.

Abstract

We examined the effects of the saturated series of fatty acids and their esters on plaque bacterial metabolism. Fatty acids with a chain length of 8-15 carbons inhibited Streptococcus mutans and dental plaque in vitro. The glycerol monoesters with a fatty acid chain of 10-14 carbons were inhibitory to a similar extent. The glycolipid (sucrose monolaurate) reduced plaque bacterial glycolysis and sucrose oxidation in a non-competitive manner but stimulated sucrose incorporation at low sucrose concentrations. The relationship between surface activity and inhibition is discussed, since this may help to explain the anti-caries effects of these compounds.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cariostatic Agents / pharmacology
  • Dental Plaque / metabolism*
  • Fatty Acids / pharmacology*
  • Glucose / metabolism
  • Glycerides / pharmacology*
  • Humans
  • Hydrogen-Ion Concentration
  • Laurates / pharmacology*
  • Lauric Acids / pharmacology*
  • Monoglycerides
  • Polysaccharides, Bacterial / metabolism
  • Streptococcus mutans / metabolism
  • Sucrose / analogs & derivatives*
  • Sucrose / metabolism*
  • Sucrose / pharmacology

Substances

  • Cariostatic Agents
  • Fatty Acids
  • Glycerides
  • Laurates
  • Lauric Acids
  • Monoglycerides
  • Polysaccharides, Bacterial
  • sucrose monolaurate
  • monolaurin
  • Sucrose
  • Glucose