Electrogenic hyperpolarization in canine cardiac Purkinje fibres exposed to calcium ionophores

Experientia. 1978 May 15;34(5):619-21. doi: 10.1007/BF01936995.

Abstract

The Ca ionophores markedly enhance the increase of intracellular Ca occurring during Na-free perfusion and the hyperpolarization observed upon Na readmission may be due to rapid restoration of intracellular Na and resultant stimulation of both electrogenic sodium and calcium efflux.

MeSH terms

  • Action Potentials / drug effects*
  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Calcium / metabolism
  • Dogs
  • Heart Conduction System / drug effects*
  • Lasalocid / pharmacology*
  • Purkinje Fibers / drug effects*
  • Purkinje Fibers / metabolism
  • Sodium / metabolism

Substances

  • Anti-Bacterial Agents
  • Sodium
  • Calcium
  • Lasalocid