Enhanced xanthine oxidase activity in mice treated with interferon and interferon inducers

Biochem Biophys Res Commun. 1984 Feb 29;119(1):144-9. doi: 10.1016/0006-291x(84)91630-9.


Administration to mice of either interferon (IFN) or IFN inducers resulted in a marked increase of xanthine oxidase (XO) activity in different organs. Dose response studies revealed that serum XO was increased by administration of polyinosylic-polycyticylic acid (poly I-C) at doses as low as 0.1 mg/kg. In view of the well known ability of XO to generate superoxide radicals it is suggested that its induction might play a role in several biological effects of IFN.

MeSH terms

  • Animals
  • DNA, Recombinant
  • Dose-Response Relationship, Drug
  • Interferon Inducers / pharmacology*
  • Interferon Type I / pharmacology*
  • Kinetics
  • Liver / enzymology
  • Male
  • Mice
  • Poly I-C / pharmacology
  • Tissue Distribution
  • Xanthine Dehydrogenase
  • Xanthine Oxidase / blood
  • Xanthine Oxidase / metabolism*


  • DNA, Recombinant
  • Interferon Inducers
  • Interferon Type I
  • Xanthine Dehydrogenase
  • Xanthine Oxidase
  • Poly I-C