A high-resolution study of chromosome changes in a human prostatic carcinoma cell line (LNCaP)

Cancer Genet Cytogenet. 1984 Apr;11(4):399-404. doi: 10.1016/0165-4608(84)90020-7.

Abstract

A high-resolution study of chromosomal rearrangements in a human prostatic cancer cell line, LNCaP, has been performed. The cytogenetic analysis revealed a pseudodiploid karyotype and the presence of seven marker chromosomes resulting from five aberrational events. The analysis of four clones derived from the original line showed a near-tetraploid chromosome number and the presence of the same seven markers observed in the original line. This is the first complete description of karyotypic rearrangements in a prostatic cancer cell line.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Line
  • Chromosome Aberrations*
  • Chromosome Banding
  • Genetic Markers
  • Humans
  • Karyotyping
  • Male
  • Ploidies
  • Prostatic Neoplasms / genetics*

Substances

  • Genetic Markers