The brush border of proximal tubules of normal human kidney activates the alternative pathway of the complement system in vitro

Ann N Y Acad Sci. 1983;420:321-4. doi: 10.1111/j.1749-6632.1983.tb22219.x.


The aim of this investigation was to study complement fixation by normal human kidney tissue. C fixation was assessed on acetone-fixed sections of frozen human kidney. In addition, C consumption following incubation of normal fresh human serum with tubular or glomerular fractions of human kidney was measured. The results are consistent with the interpretation that the brush border of proximal tubules of human kidney activates the C system via the alternative pathway. It is suggested that this activation may occur in vivo in patients with a non-selective proteinuria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Complement Activation*
  • Complement Pathway, Alternative*
  • Humans
  • Kidney Tubules, Proximal / immunology*
  • Microvilli / immunology