Extended haplotypes of chromosome 6 in adult rheumatoid arthritis

Arthritis Rheum. 1984 May;27(5):516-21. doi: 10.1002/art.1780270506.

Abstract

In 46 patients with rheumatoid arthritis (RA) the allele C4B*3 occurred in 6 patients, while among 350 normal controls, it occurred 6 times (P less than 0.00002). Among 9 white and 1 black families, each of which had 2 or more members with RA, there were 36 haplotypes associated with RA. An extended haplotype (specific HLA-B, DR, complotype haplotypes in significant linkage disequilibrium) containing C4B*3: HLA-B15, DR4, BF*S, C2*C, C4A*3, C4B*3, was found twice (P less than 0.001) among whites with the disease-associated chromosomes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Alleles
  • Arthritis, Rheumatoid / genetics*
  • Blacks
  • Chromosome Mapping
  • Chromosomes, Human, 6-12 and X
  • Complement System Proteins / genetics
  • Gene Frequency
  • HLA Antigens / genetics
  • HLA-B Antigens
  • Haploidy
  • Humans
  • Major Histocompatibility Complex
  • Whites

Substances

  • HLA Antigens
  • HLA-B Antigens
  • Complement System Proteins