In vivo evidence for prostaglandin inhibitory activity in New Zealand green-lipped mussel extract

N Z Med J. 1984 Jun 13;97(757):355-7.


Prostaglandin synthetase inhibitors (eg, aspirin, indomethacin and naproxen) interfere with ovulation and prolong the gestation period in the rat. These properties could provide a novel test bed for the assessment of agents with prostaglandin biosynthesis inhibitory activity. Rats were fed green-lipped mussel extract and the effects on conception and the subsequent gestation period were determined. Parturition was delayed and fetal development was retarded in the Seatone-fed animals. The observations were consistent with the known effects of nonsteroidal anti-inflammatory drugs, suggesting that Seatone does contain pharmacologically active material inhibiting prostaglandin biosynthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Anti-Inflammatory Agents / toxicity
  • Body Height / drug effects
  • Body Weight / drug effects
  • Female
  • Fetal Growth Retardation / chemically induced
  • Fetus / drug effects
  • Labor, Obstetric / drug effects
  • Male
  • Pregnancy
  • Prostaglandin Antagonists*
  • Prostaglandins / biosynthesis*
  • Rats
  • Rats, Inbred Strains
  • Teratogens
  • Tissue Extracts / pharmacology*
  • Tissue Extracts / toxicity


  • Anti-Inflammatory Agents
  • Prostaglandin Antagonists
  • Prostaglandins
  • Seatone
  • Teratogens
  • Tissue Extracts