Chromosomal assignments of human genes for serine proteases trypsin, chymotrypsin B, and elastase

Somat Cell Mol Genet. 1984 Jul;10(4):369-76. doi: 10.1007/BF01535632.


The genes for the serine proteases trypsin, chymotrypsin B, and elastase were chromosomally assigned in man using cDNA probes that have been isolated from a rat pancreatic cDNA library. DNA from human X rodent somatic cell hybrids was cleaved with BamHI or EcoRI and analyzed by Southern filter hybridization methods for the segregation of the genes for trypsin-1 (TRY1), chymotrypsin B (CTRB), and elastase-1 (ELA1). TRY1 was assigned to human chromosome 7q22----qter, CTRB to chromosome 16, and ELA1 to chromosome 12. Although the three genes are members of the same gene family, they are dispersed over different chromosomes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biological Evolution
  • Chromosome Mapping
  • Chromosomes, Human, 16-18*
  • Chromosomes, Human, 6-12 and X*
  • Chymotrypsin / genetics*
  • DNA / genetics
  • Genes
  • Humans
  • Pancreatic Elastase / genetics*
  • Trypsin / genetics*


  • DNA
  • Chymotrypsin
  • Pancreatic Elastase
  • Trypsin