Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse

Somat Cell Mol Genet. 1984 Jul;10(4):377-83. doi: 10.1007/BF01535633.

Abstract

The mouse genes for the serine proteases trypsin (Try-1), chymotrypsin B (Ctrb), and elastase (Ela-1) were chromosomally assigned using Southern blot hybridization of mouse X Chinese hamster cell hybrid DNA. cDNA probes for the three genes were hybridized to cell hybrid DNA cleaved with BamHI or HindIII and the segregation of Try-1, Ctrb, and Ela-1 was correlated with the segregation of mouse chromosomes. Try-1 is located on chromosome 6, Ctrb is on chromosome 8, and Ela-1 is on chromosome 15. The three genes fall into three syntenic groups that are conserved in the mouse and human genomes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biological Evolution
  • Chromosome Mapping
  • Chymotrypsin / genetics
  • DNA / genetics
  • Genes
  • Mice / genetics*
  • Pancreatic Elastase / genetics
  • Trypsin / genetics

Substances

  • DNA
  • Chymotrypsin
  • Pancreatic Elastase
  • Trypsin