Brain sarcoma of meningeal origin after cranial irradiation in childhood acute lymphocytic leukemia. Case report

J Neurosurg. 1984 Oct;61(4):772-6. doi: 10.3171/jns.1984.61.4.0772.


The authors report their experience with an unusual case of intracerebral sarcoma of meningeal cell origin in an 8 1/2-year-old girl. This tumor occurred 6 1/2 years after cranial irradiation at relatively low dosage (2200 rads) had been delivered to the head in the course of a multimodality treatment for acute lymphocytic leukemia. The tumor recurred approximately 10 months after the first surgical intervention. Macroscopic total excision of the recurrent growth followed by whole-brain irradiation (4500 rads) failed to eradicate it completely and local recurrence prompted reoperation 18 months later. This complication of treatment in long-term childhood leukemia survivors is briefly discussed, as well as the pathology of meningeal sarcomas.

Publication types

  • Case Reports

MeSH terms

  • Brain Neoplasms / etiology*
  • Brain Neoplasms / pathology
  • Brain Neoplasms / surgery
  • Child, Preschool
  • Female
  • Humans
  • Leukemia, Lymphoid / radiotherapy*
  • Meningeal Neoplasms / etiology
  • Meningeal Neoplasms / pathology
  • Meningeal Neoplasms / surgery
  • Neoplasms, Radiation-Induced / pathology*
  • Neoplasms, Radiation-Induced / surgery
  • Sarcoma / etiology*
  • Sarcoma / pathology
  • Sarcoma / surgery