Molecular cloning of a new transforming gene from a chemically transformed human cell line

Nature. 1984 Sep 6-11;311(5981):29-33. doi: 10.1038/311029a0.

Abstract

Molecular cloning of the transforming gene from a chemically transformed human osteosarcoma-derived cell line enables the gene to be mapped to chromosome 7 (7p11.4-7qter) and by this criterion and by direct hybridization to be shown to be unrelated to known oncogenes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Cell Line
  • Cell Transformation, Neoplastic*
  • Cells, Cultured
  • Chromosome Mapping
  • Chromosomes, Human, 6-12 and X
  • Cloning, Molecular*
  • Humans
  • Hybrid Cells / physiology
  • Mice
  • Mice, Inbred Strains
  • Nucleic Acid Hybridization
  • Oncogenes*
  • Osteosarcoma / genetics*