Oral isotretinoin therapy. Use in a patient with multiple cutaneous squamous cell carcinomas and keratoacanthomas

Arch Dermatol. 1984 Sep;120(9):1215-7. doi: 10.1001/archderm.120.9.1215.

Abstract

An 83-year-old woman with multiple squamous cell carcinomas and keratoacanthomas of the legs was treated with orally administered isotretinoin (13 cis-retinoic acid). Complete regression of the tumors was noted during the initial six-month treatment period. In the subsequent 36 months, four new cutaneous tumors were excised. There have been no recurrences of lesions that regressed while the patient was receiving retinoid therapy.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Aged
  • Carcinoma, Squamous Cell / drug therapy*
  • Carcinoma, Squamous Cell / pathology
  • Female
  • Humans
  • Isotretinoin
  • Keratoacanthoma / drug therapy*
  • Keratoacanthoma / pathology
  • Leg / pathology
  • Skin Diseases / drug therapy*
  • Skin Diseases / pathology
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / pathology
  • Tretinoin / administration & dosage
  • Tretinoin / therapeutic use*

Substances

  • Tretinoin
  • Isotretinoin