The iron-hydrogen peroxide-iodide system is fungicidal: activity against the yeast phase of Blastomyces dermatitidis

J Leukoc Biol. 1984 Oct;36(4):545-8. doi: 10.1002/jlb.36.4.545.

Abstract

A series of experiments show the potency of a newly described microbicidal system, involving iron, H2O2, and halide, in killing a fungus (Blastomyces dermatitidis). B dermatitidis has previously been shown susceptible to the myeloperoxidase-H2O2-halide system. The present studies show killing of either of two strains in 1 hour if Fe++ at 5 X 10(-5)M, H2O2 at 5 X 10(-5)M and Kl at 5 X 10(-4)M are all present (P less than 0.001). EDTA, a Fe++ chelator, abrogates killing. The mechanism presumably utilizes hydroxyl radical, since an inhibitor, ethanol, also neutralizes the system. The bactericidal and fungicidal system is of great potential importance in vivo.

Publication types

  • Comparative Study

MeSH terms

  • Antifungal Agents / pharmacology*
  • Blastomyces / drug effects*
  • Hydrogen Peroxide / pharmacology*
  • Iodides / pharmacology*
  • Iron / pharmacology*
  • Species Specificity

Substances

  • Antifungal Agents
  • Iodides
  • Hydrogen Peroxide
  • Iron