Inhibition of aortic vessel adenosine diphosphate degradation by cadmium and mercury

Arch Toxicol Suppl. 1984:7:378-81. doi: 10.1007/978-3-642-69132-4_64.

Abstract

The effects of cadmium and mercury on ADP breakdown by vessel walls were investigated. These metals reduce the ADP clearance promoted by arterial tissue. This effect could be attributed to the inhibition of vessel wall ADP-ase enzyme, which plays an important role in the genesis of thrombotic phenomena.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Diphosphate / metabolism*
  • Animals
  • Aorta / metabolism
  • Cadmium / pharmacology*
  • Male
  • Mercury / pharmacology*
  • Muscle, Smooth, Vascular / metabolism*
  • Rats
  • Rats, Inbred Strains

Substances

  • Cadmium
  • Adenosine Diphosphate
  • Mercury