An age-structured model of pre- and post-vaccination measles transmission

IMA J Math Appl Med Biol. 1984;1(2):169-91. doi: 10.1093/imammb/1.2.169.


An infection like measles does not spread uniformly in populations from Europe and North America. Of special importance is a pronounced age-dependency in the contact rates, because of increased infection transmission within schools. Therefore an age-structured epidemiologic model is investigated here, which also pays attention to the fact that children are promoted grade-wise into and out of school. Simulation results are contrasted with pre- and post-vaccination measles data from England and Wales and the model is shown to perform better than previous global mass-action models.

Publication types

  • Comparative Study

MeSH terms

  • Age Factors
  • Biometry
  • Child
  • England
  • Humans
  • Measles / epidemiology
  • Measles / prevention & control
  • Measles / transmission*
  • Models, Theoretical*
  • Vaccination*
  • Wales