Clinical features of patients with antibodies directed against proliferating cell nuclear antigen

Arthritis Rheum. 1983 Feb;26(2):140-5. doi: 10.1002/art.1780260204.


The clinical and serologic features of 7 patients whose sera contained antibodies directed against proliferating cell nuclear antigen (anti-PCNA) were studied. Five of the patients had systemic lupus erythematosus (SLE), 1 had idiopathic diffuse proliferative glomerulonephritis, and 1 had seronegative arthritis. In a study of various rheumatic diseases, anti-PCNA was found in 2% of SLE sera but was not found in the sera of 100 rheumatoid arthritis patients, 20 mixed connective tissue disease patients, or 50 diffuse scleroderma patients. Patients with anti-PCNA had no history of hemolytic anemia, leukopenia, thrombocytopenia, or pleuro-pericarditis. Evidence that the production of anti-PCNA antibodies is sensitive to corticosteroid therapy is also presented.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Antinuclear / analysis*
  • Antigens / immunology*
  • Antigens, Nuclear
  • Arthritis, Rheumatoid / immunology*
  • Autoantibodies / analysis
  • Autoantigens
  • Cell Division
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / diagnosis
  • Lupus Erythematosus, Systemic / immunology*
  • Male
  • Middle Aged
  • Mixed Connective Tissue Disease / immunology
  • Nucleoproteins / immunology*
  • Ribonucleoproteins, Small Nuclear*
  • Scleroderma, Systemic / immunology
  • snRNP Core Proteins


  • Antibodies, Antinuclear
  • Antigens
  • Antigens, Nuclear
  • Autoantibodies
  • Autoantigens
  • Nucleoproteins
  • Ribonucleoproteins, Small Nuclear
  • snRNP Core Proteins