Modulatory actions of ATP on membrane potentials of bullfrog sympathetic ganglion cells

Brain Res. 1983 Jan 10;258(2):313-7. doi: 10.1016/0006-8993(83)91157-5.


Adenosine triphosphate (ATP) depolarized the membrane of bullfrog sympathetic ganglion cells by decreasing resting K+ conductance. ATP also depressed the maximum amplitude of after-hyperpolarization of action potentials. Voltage-clamp study revealed that ATP markedly suppressed the TEA-insensitive K+ current which appeared to correspond to the M-current, while it affected less significantly on the delayed rectifier K+ current. It was suggested that ATP depolarized resting membrane by suppressing resting K+ conductances, including the M-current, and also depressed the after-hyperpolarization of action potentials by suppressing both the M-current and delayed rectifier K+ current.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects
  • Adenosine Diphosphate / pharmacology
  • Adenosine Monophosphate / pharmacology
  • Adenosine Triphosphate / pharmacology*
  • Animals
  • Ganglia, Sympathetic / drug effects
  • Ganglia, Sympathetic / physiology*
  • Kinetics
  • Membrane Potentials / drug effects
  • Potassium / pharmacology
  • Rana catesbeiana
  • Tetrodotoxin / pharmacology


  • Adenosine Monophosphate
  • Tetrodotoxin
  • Adenosine Diphosphate
  • Adenosine Triphosphate
  • Potassium