Peripheral blood T lymphocytes subpopulations in HLA-B7 related rheumatic diseases: ankylosing spondylitis and reactive synovitis

J Rheumatol. 1983 Feb;10(1):140-3.

Abstract

The etiology of B lymphocyte hyperactivity in ankylosing spondylitis (AS) and in reactive synovitis is unknown and data available on the cellular immune system are controversial. We therefore evaluated peripheral blood T cell populations in AS patients and patients with reactive synovitis (RS) using monoclonal antibodies, previously shown to react with all T cells (OKT3), the inducer-helper T cell subset (OKT4) and the suppressor-cytotoxic T cell subset (OKT8). Results were compared with a normal control group and a group of rheumatoid arthritis (RA) patients. In AS an increase of OKT4+ cells was found, but the total number of T helper-inducer cells in peripheral blood was not different from the normal group and the group of patients with RS. Contrary to the results found in RA, where the helper-inducer/suppressor-cytotoxic ratio (OKT4+/OKT8+) was significantly increased, the immunoregulatory ratio in AS and in RS was normal suggesting another mechanism leading to B cell hyperactivity than in RA.

MeSH terms

  • Adult
  • Antibodies, Monoclonal
  • Arthritis, Rheumatoid / immunology*
  • HLA Antigens / analysis*
  • HLA-B27 Antigen
  • Humans
  • Leukocyte Count
  • Middle Aged
  • Spondylitis, Ankylosing / immunology*
  • Synovitis / immunology*
  • T-Lymphocytes / classification*

Substances

  • Antibodies, Monoclonal
  • HLA Antigens
  • HLA-B27 Antigen