The immune response of the mouse to lymphocytic choriomeningitis virus. III. Differences of numbers of cytotoxic T lymphocytes in spleens of mice of different strains

Cell Immunol. 1983 Apr 15;77(2):279-89. doi: 10.1016/0008-8749(83)90028-x.


By use of an accurate procedure for the measurement of relative numbers of murine cytotoxic T lymphocytes (CTL) marked differences of lymphocytic choriomeningitis virus-specific CTL in spleens were found among mouse strains that ranged from low over intermediate and high to very high, suggesting a gradient of responses rather than distinct classes. Differences were also found between mice sharing the major histocompatibility complex.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cytotoxicity, Immunologic*
  • Fibroblasts
  • H-2 Antigens
  • Hybridization, Genetic
  • L Cells
  • Lymphocytic Choriomeningitis / immunology*
  • Lymphocytic choriomeningitis virus / immunology*
  • Lymphocytic choriomeningitis virus / physiology
  • Mice
  • Mice, Inbred Strains
  • Spleen / immunology
  • T-Lymphocytes, Cytotoxic / immunology*
  • Virus Replication


  • H-2 Antigens