Clot-selective coronary thrombolysis with tissue-type plasminogen activator

Science. 1983 Jun 10;220(4602):1181-3. doi: 10.1126/science.6602378.

Abstract

Coronary thrombolysis, an intervention that can abort the sequelae of acute myocardial infarction, was accomplished within 10 minutes in dogs by intravenous administration of clot-selective, tissue-type plasminogen activator. In addition to inducing clot lysis, this promising fibrinolytic agent restored intermediary metabolism and nutritional myocardial blood flow, detectable noninvasively with positron tomography, without inducing a systemic fibrinolytic state.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Coronary Disease / diagnostic imaging
  • Coronary Disease / drug therapy*
  • Dogs
  • Fibrinogen / analysis
  • Infusions, Parenteral
  • Injections
  • Plasminogen Activators / administration & dosage
  • Plasminogen Activators / therapeutic use*
  • Streptokinase / administration & dosage
  • Streptokinase / therapeutic use
  • Time Factors
  • Tomography, Emission-Computed

Substances

  • Fibrinogen
  • Streptokinase
  • Plasminogen Activators