Abstract
Coronary thrombolysis, an intervention that can abort the sequelae of acute myocardial infarction, was accomplished within 10 minutes in dogs by intravenous administration of clot-selective, tissue-type plasminogen activator. In addition to inducing clot lysis, this promising fibrinolytic agent restored intermediary metabolism and nutritional myocardial blood flow, detectable noninvasively with positron tomography, without inducing a systemic fibrinolytic state.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Coronary Disease / diagnostic imaging
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Coronary Disease / drug therapy*
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Dogs
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Fibrinogen / analysis
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Infusions, Parenteral
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Injections
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Plasminogen Activators / administration & dosage
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Plasminogen Activators / therapeutic use*
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Streptokinase / administration & dosage
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Streptokinase / therapeutic use
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Time Factors
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Tomography, Emission-Computed
Substances
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Fibrinogen
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Streptokinase
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Plasminogen Activators