The effect of coumarin derivatives on the immunological system of man

Agents Actions. 1983 Feb;13(1):50-2. doi: 10.1007/BF01994281.


Peripheral blood lymphocyte mitogen responsiveness was studied in 12 normal and 51 cancer patients. One group of patients was treated with warfarin, the second group with coumarin. There was a significant increase in lymphocyte response to phytohaemagglutinin (PHA) following both drugs. This increase indicates that both agents are capable of activating lymphocytes and thus stimulating some immunological functions.

MeSH terms

  • Coumarins / pharmacology*
  • Humans
  • Immunity / drug effects*
  • Neoplasms / immunology
  • Rosette Formation
  • T-Lymphocytes / drug effects
  • Warfarin / pharmacology


  • Coumarins
  • Warfarin