Pregnancy hormone concentrations in marijuana users

Life Sci. 1983 Jul 11;33(2):195-9. doi: 10.1016/0024-3205(83)90413-7.


The maternal serum concentrations of human chorionic gonadotropin, pregnancy-specific beta-l-glycoprotein, placental lactogen, progesterone, 17-hydroxyprogesterone, estradiol and estriol were measured in 13 women who smoked marijuana regularly throughout pregnancy. Cannabinoid use in these women was confirmed by RIA measurements of their serum delta 9-tetrahydrocannabinol (THC) concentrations. These THC using women were matched within 2 1/2 weeks of gestational age with 13 pregnant non-THC using controls drawn from the same population. Placental protein and steroid hormone concentrations were within established normal ranges for gestational age and there were no significant differences between the groups in the concentrations of any of the protein and steroids measured. In addition, no significant differences between THC users were found following linear regression analysis of placental hormone concentrations as a function of gestational age. Thus, this study suggests that marijuana use during pregnancy does not significantly alter the circulating maternal concentrations of trophoblastic protein hormones or major fetoplacental steroid hormones.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cannabis*
  • Chorionic Gonadotropin / blood
  • Estradiol / blood
  • Estriol / blood
  • Female
  • Gestational Age
  • Humans
  • Hydroxyprogesterones / blood
  • Placental Lactogen / blood
  • Pregnancy
  • Pregnancy Proteins / blood*
  • Pregnancy-Specific beta 1-Glycoproteins / analysis
  • Progesterone / blood


  • Chorionic Gonadotropin
  • Hydroxyprogesterones
  • Pregnancy Proteins
  • Pregnancy-Specific beta 1-Glycoproteins
  • Progesterone
  • Estradiol
  • Placental Lactogen
  • Estriol