Angiotensinogen is related to the antitrypsin-antithrombin-ovalbumin family

Science. 1983 Oct 28;222(4622):417-9. doi: 10.1126/science.6604942.


The recently reported amino acid sequence of rat angiotensinogen was subjected to a computer-assisted search for homology with known sequences stored in a data bank and found to be significantly related to that of plasma alpha 1-antitrypsin, itself a member of a family that includes antithrombin III and ovalbumin. An alignment of the four sequences shows indisputably the common ancestry of all four proteins.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Angiotensinogen / genetics*
  • Angiotensins / genetics*
  • Animals
  • Antithrombins / genetics
  • Biological Evolution*
  • Macromolecular Substances
  • Ovalbumin / genetics
  • Rats
  • alpha 1-Antitrypsin / genetics


  • Angiotensins
  • Antithrombins
  • Macromolecular Substances
  • alpha 1-Antitrypsin
  • Angiotensinogen
  • Ovalbumin