The major histocompatibility complex-restricted antigen receptor on T cells in mouse and man: identification of constant and variable peptides

Cell. 1983 Nov;35(1):295-302. doi: 10.1016/0092-8674(83)90232-5.


The variability of the MHC restricted receptor on murine T cells was examined by comparing tryptic peptide fingerprints of the receptor isolated fom three T cell hybridomas and a T cell tumor. Both variable and constant peptides were seen. Constant peptides were most apparent when comparing receptors from the same mouse strain. Peptide fingerprints of receptors from two independent T cell hybridomas with the same idiotype and specificity were identical. We also describe a molecule detected on the surface of a human T cell leukemia whose properties were identical to those reported for the MHC receptor on normal human T cells. The molecule was a dimer of 85,000-90,000 MW containing a 46,000 MW acidic alpha-chain and an unrelated 40,000 MW neutral beta-chain.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Line
  • Humans
  • Hybridomas
  • Leukemia, Lymphoid / immunology
  • Major Histocompatibility Complex*
  • Mice
  • Mice, Inbred BALB C
  • Molecular Weight
  • Peptides / analysis*
  • Receptors, Antigen, T-Cell / analysis*
  • Species Specificity
  • T-Lymphocytes / immunology*
  • Trypsin


  • Peptides
  • Receptors, Antigen, T-Cell
  • Trypsin