Effect of estrogen on vitamin D metabolism in tall girls

J Clin Endocrinol Metab. 1983 Dec;57(6):1155-8. doi: 10.1210/jcem-57-6-1155.


To determine the effect of estrogen on vitamin D metabolism in pubertal girls, we studied 16 tall girls treated with a daily dose of 4-8 mg estradiol valerate to curtail excessive adult height. In all but one girl the plasma concentration of 1,25-dihydroxyvitamin D (1,25-(OH)2D) increased to values significantly higher than the corresponding pretreatment value (P less than 0.0005). The ratio of 24,25-dihydroxyvitamin D (24,25-(OH)2D) to 25-hydroxyvitamin D decreased in all girls (P less than 0.0005). The vitamin D binding protein (DBP) also increased significantly after estrogen (P less than 0.025), and there was a significant positive correlation between the plasma concentration of 1,25-(OH)2D and DBP (r = 0.66; P less than 0.0005). The free fraction of 1,25-(OH)2D remained unchanged after estrogen. It appears that estrogen treatment increases the plasma concentration of 1,25-(OH)2D. The effect might be explained by the concomitant increase in DBP and/or by estrogen stimulation of renal 1 alpha-hydroxylase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 24,25-Dihydroxyvitamin D 3
  • Adolescent
  • Body Height*
  • Calcifediol / blood
  • Calcitriol / blood
  • Carrier Proteins / blood
  • Child
  • Dihydroxycholecalciferols / blood
  • Estradiol / analogs & derivatives*
  • Estradiol / pharmacology
  • Estradiol / therapeutic use
  • Female
  • Humans
  • Vitamin D / blood*
  • Vitamin D-Binding Protein


  • Carrier Proteins
  • Dihydroxycholecalciferols
  • Vitamin D-Binding Protein
  • Vitamin D
  • 24,25-Dihydroxyvitamin D 3
  • Estradiol
  • Calcitriol
  • Calcifediol