Primary Amino Acid Sequence Similarity Between Human Epidermal Growth Factor-Urogastrone, Human Pancreatic Secretory Trypsin Inhibitor, and Members of Porcine Secretin Family

Arch Biochem Biophys. 1983 Oct 15;226(2):411-3. doi: 10.1016/0003-9861(83)90309-0.


Sequence similarities are detected between human epidermal growth factor-urogastrone, human pancreatic secretory trypsin inhibitor, and members of the secretin family of gastrointestinal hormones, particularly gastric inhibitory peptide. These similarities suggest a common evolutionary origin for these proteins and a possible functional relationship, as evidenced by the ability of human epidermal growth factor-urogastrone and human pancreatic secretory trypsin inhibitor to form a complex with protease and the ability of human epidermal growth factor-urogastrone and secretin family members to inhibit gastric acid secretion.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Epidermal Growth Factor*
  • Humans
  • Pancreas
  • Secretin*
  • Swine
  • Trypsin Inhibitor, Kazal Pancreatic*
  • Trypsin Inhibitors*


  • Trypsin Inhibitors
  • Secretin
  • Trypsin Inhibitor, Kazal Pancreatic
  • Epidermal Growth Factor