The risk of developing ankylosing spondylitis in HLA-B27 positive individuals: a family and population study

Br J Rheumatol. 1983 Nov;22(4 Suppl 2):18-9. doi: 10.1093/rheumatology/xxii.suppl_2.18.


In a family study, sacroiliitis was found in 15 (25%) out of 61 HLA-B27 positive first-degree relatives (FDR) of 20 randomly chosen HLA-B27 positive ankylosing spondylitis (AS) patients and never in 41 HLA-B27 negative FDR. Eight (53%) of the 15 FDR with sacroiliitis fulfilled the New York criteria for AS. In the population study the prevalence of HLA-B27 positive AS was found to be 0.1%. AS will develop in 1.3% of all HLA-B27 positive individuals belonging to the general population.

MeSH terms

  • Adult
  • Female
  • Genetics, Population*
  • HLA Antigens / genetics*
  • HLA-B27 Antigen
  • Humans
  • Male
  • Middle Aged
  • Netherlands
  • Risk
  • Spondylitis, Ankylosing / genetics*
  • Spondylitis, Ankylosing / immunology


  • HLA Antigens
  • HLA-B27 Antigen