Genetic control of T-cell subset representation in inbred mice

Immunogenetics. 1983;18(6):585-92. doi: 10.1007/BF00345966.


Lyt-2+ T cells constitute a significantly greater proportion of the total peripheral T-cell population in C57BL mice than in BALB/c and other mouse strains. The inheritance of this differential representation of Lyt-2- vs. Lyt-2+ T cells was studied by two-color immunofluorescence analysis of peripheral T cell subsets in BALB/c, C57BL, F1 and F2 generations, and in CXB recombinant inbred strains. It was shown that the C57BL phenotype (low Lyt-2-/Lyt-2+ ratio) is a dominant Mendelian character. Studies of subpopulations of thymocytes and of early thymus emigrants indicate that the representation of mature Lyt-2- and Lyt-2+ T cells is influenced by mechanisms of selection or differential turnover in the peripheral lymphoid organs, but that thymic and prethymic influences may also play a role.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens, Ly
  • Cell Count
  • Genes, Dominant
  • H-2 Antigens / genetics
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred Strains / genetics*
  • Recombination, Genetic
  • T-Lymphocytes / immunology*
  • Thymus Gland / immunology


  • Antigens, Ly
  • H-2 Antigens