Alternative approach to single-scan estimation of cerebral glucose metabolic rate using glucose analogs, with particular application to ischemia

J Cereb Blood Flow Metab. 1984 Mar;4(1):35-40. doi: 10.1038/jcbfm.1984.5.


In the glucose analog method for determining local glucose utilization rates, time courses of tissue and plasma radioactivity are measured and then analyzed in terms of first-order exchange of label between tissue compartments. The rate of glucose utilization is assumed to have a fixed, linear relationship to the analog phosphorylation rate calculated from the fitted rate constants. Accurate estimation of the rate constants requires many hours of dynamic data acquisition. Therefore, techniques assuming a linear relationship between analog phosphorylation rate and total tissue concentration of label were developed to predict glucose utilization rates from a single scan. Previously reported linearizations differ in their sensitivity to differences between current and average kinetic rate constants, and thus in their accuracy. We have developed a method that is insensitive to the presumed value of the blood flow-capillary wall transport parameter k1. This new single-scan approach has been validated by comparison of the single-scan metabolic rate values with the values calculated from the dynamic measurements.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Autoradiography
  • Brain / diagnostic imaging
  • Brain / metabolism*
  • Brain Ischemia / diagnostic imaging
  • Brain Ischemia / metabolism*
  • Carbon Radioisotopes
  • Deoxyglucose
  • Glucose / metabolism*
  • Humans
  • Kinetics
  • Methods
  • Models, Biological
  • Phosphorylation
  • Tomography, Emission-Computed*


  • Carbon Radioisotopes
  • Deoxyglucose
  • Glucose