Cytokines and the chronic inflammation of rheumatic disease. I. The presence of interleukin-1 in synovial fluids

Clin Exp Immunol. 1984 Feb;55(2):295-302.


Synovial fluids from patients with rheumatoid arthritis (13 cases), ankylosing spondylitis (six), psoriatic arthritis (two), osteoarthritis (three) and rubella arthritis (four) contain interleukin-1 (Il-1) activity as measured in the CH3/He mouse thymocyte assay. That this activity is Il-1 was shown by: (i) the time course of thymocyte stimulation; (ii) failure of PHA blast cells to absorb out the activity; (iii) molecular weight of 15,000-20,000 daltons, and (iv) ability to stimulate prostaglandin E2 production from synovial cells. These results indicate that IL-1 is an important mediator in the inflammatory pathway of different types of joint disease.

MeSH terms

  • Animals
  • Arthritis / immunology*
  • Arthritis, Rheumatoid / immunology
  • Cell Division
  • Chromatography, Gel
  • Dinoprostone
  • Humans
  • Interleukin-1 / analysis*
  • Lymphocyte Activation
  • Mice
  • Molecular Weight
  • Osteoarthritis / immunology
  • Prostaglandins E / biosynthesis
  • Spondylitis, Ankylosing / immunology
  • Synovial Fluid / immunology*
  • T-Lymphocytes / immunology
  • Time Factors


  • Interleukin-1
  • Prostaglandins E
  • Dinoprostone