Studies of peripheral blood lymphocytes in Crohn's disease. Circulating activated T cells

Scand J Gastroenterol. 1983 Nov;18(8):1003-8. doi: 10.3109/00365528309181833.


Peripheral blood mononuclear cells have been investigated in 43 patients with Crohn's disease (CD) by means of a panel of 4 monoclonal antibodies (UCHT1, UCHT4, 4F2, 5E9). A decrease of total T cells (UCHT1+) (p less than 0.01) and a slight increase of cytotoxic/suppressor T cells (UCHT4+) were observed. Evidence of T-cell activation, as shown by the highly significant increase of 4F2+ and 5E9+ cells, was also found. The latter finding lends support to the concept that cell-mediated immune phenomena are an important feature in CD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Monoclonal
  • Crohn Disease / immunology*
  • Female
  • Humans
  • Lymphocyte Activation
  • Lymphocytes / immunology*
  • Male
  • T-Lymphocytes / classification


  • Antibodies, Monoclonal