Effect of dental amalgam and nickel alloys on T-lymphocytes: preliminary report

J Prosthet Dent. 1984 May;51(5):617-23. doi: 10.1016/0022-3913(84)90404-9.


Preliminary data suggest that dental amalgam and dental nickel alloys can adversely affect the quantity of T-lymphocytes. Human T-lymphocytes can recognize specific antigens, execute effector functions, and regulate the type and intensity of virtually all cellular and humoral immune responses. Normal immune function depends on a proper quantity, quality, and ratio of T-lymphocyte helper and suppressor subsets. Further research may determine the frequency and magnitude of T-lymphocyte reduction and alteration by dental materials.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Biocompatible Materials
  • Dental Alloys / pharmacology*
  • Dental Amalgam / pharmacology*
  • Female
  • Humans
  • Leukocyte Count*
  • Lymphopenia / etiology
  • Male
  • Nickel / pharmacology*
  • T-Lymphocytes / cytology
  • T-Lymphocytes / drug effects*


  • Biocompatible Materials
  • Dental Alloys
  • Nickel
  • Dental Amalgam