Estimation of fixation indices and gene diversities

Ann Hum Genet. 1983 Jul;47(3):253-9. doi: 10.1111/j.1469-1809.1983.tb00993.x.


Considering the multinomial sampling of genotypes, unbiased estimators of various gene diversity measures in subdivided populations are presented. Using these quantities, formulae for estimating Wright's fixation indices (FIS, FIT, and FST) from a finite sample are developed.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acid Phosphatase / genetics
  • Gene Frequency
  • Genetic Variation*
  • Genotype
  • Heterozygote
  • Humans
  • Israel
  • Jews
  • Models, Genetic*


  • Acid Phosphatase