Lymphocytic hypophysitis. Associated with antiparietal cell antibodies and vitamin B12 deficiency

Arch Intern Med. 1983 Sep;143(9):1794-5. doi: 10.1001/archinte.143.9.1794.


Lymphocytic hypophysitis has been recognized as a distinct clinicopathologic entity. It is a cause of hypopituitarism in the postpartum period and is believed to have an autoimmune pathogenesis. We treated a patient with lymphocytic hypophysitis with two unique features. First, this patient had had a prolactin level of 101 ng/mL (normal, 0 to 25 ng/mL). To our knowledge, this degree of elevation has not been previously reported and is a level that might cause confusion with prolactin-secreting pituitary adenomas. Second, this patient had positive titers for antiparietal cell antibodies in conjunction with a low vitamin B12 level and anemia. To our knowledge, this is the first report of a clinically important autoantibody to extrapituitary tissue in a living patient with lymphocytic hypophysitis.

Publication types

  • Case Reports

MeSH terms

  • Antibodies / analysis
  • Female
  • Humans
  • Hypopituitarism / diagnosis*
  • Hypopituitarism / immunology
  • Middle Aged
  • Vitamin B 12 Deficiency / diagnosis*
  • Vitamin B 12 Deficiency / immunology


  • Antibodies