Proposed mechanism of ataxia in Fisher's syndrome

Arch Neurol. 1983 Sep;40(9):537-8. doi: 10.1001/archneur.1983.04050080037004.


A patient with Fisher's variant of Guillain-Barré syndrome had severe limb ataxia. Joint position sense was diminished proximally but normal distally. In contrast, muscle proprioceptive function, studied electrophysiologically by recording silent periods in proximal muscles, appeared to be normal. A disparity between proprioceptive information from muscle spindles and kinesthetic information from joints and other proprioceptors may be a mechanism of ataxia, based solely on abnormalities of peripheral nerve function. A CNS lesion is, therefore, not necessary to explain cerebellar ataxia in Fisher's syndrome.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Ataxia / complications
  • Ataxia / physiopathology*
  • Biomechanical Phenomena
  • Electromyography
  • Electrophysiology
  • Humans
  • Male
  • Neural Conduction
  • Peripheral Nerves / physiopathology
  • Polyradiculoneuropathy / complications*