Colonic release of 5-amino salicylic acid from an oral preparation in active ulcerative colitis

Br J Clin Pharmacol. 1983 Aug;16(2):185-7. doi: 10.1111/j.1365-2125.1983.tb04983.x.


5-amino salicylic acid coated with acrylic based resin was given orally to eight patients with active ulcerative colitis. Abdominal X-rays confirmed that the preparation released its contents in the terminal ileum and proximal colon. Differences between individuals were marked; the plasma 'concentration-time profile' reflected variations in the time taken for tablets to reach the terminal ileum.

MeSH terms

  • Adult
  • Aged
  • Aminosalicylic Acids / administration & dosage
  • Aminosalicylic Acids / blood
  • Aminosalicylic Acids / metabolism*
  • Colitis, Ulcerative / metabolism*
  • Colon / metabolism*
  • Female
  • Humans
  • Intestines / diagnostic imaging
  • Male
  • Mesalamine
  • Middle Aged
  • Radiography
  • Tablets, Enteric-Coated
  • Time Factors


  • Aminosalicylic Acids
  • Tablets, Enteric-Coated
  • Mesalamine