Enzyme induction with rifampicin; lipoproteins and drug binding to alpha 1-acid glycoprotein

Br J Clin Pharmacol. 1983 Aug;16(2):195-7. doi: 10.1111/j.1365-2125.1983.tb04986.x.


Hepatic enzyme induction has been reported to increase lignocaine binding, alpha 1-acid glycoprotein concentration and high density lipoprotein (HDL) cholesterol. In eight volunteers treated with rifampicin for 3 weeks there was no significant alteration in these three variables although their antipyrine clearance was significantly increased. In 10 patients with pulmonary tuberculosis treated with rifampicin (mean 5 months) the degree of serum protein binding of lignocaine, alpha 1-acid glycoprotein and HDL-cholesterol concentration was not different from that of matched control patients. These results suggest that differential induction of these variables may occur.

MeSH terms

  • Adult
  • Aged
  • Cholesterol / blood
  • Enzyme Induction / drug effects*
  • Female
  • Humans
  • Lidocaine / blood
  • Lipoproteins / blood*
  • Male
  • Middle Aged
  • Orosomucoid / metabolism*
  • Protein Binding / drug effects
  • Rifampin / pharmacology*


  • Lipoproteins
  • Orosomucoid
  • Cholesterol
  • Lidocaine
  • Rifampin