The complete amino acid sequence of oncomodulin--a parvalbumin-like calcium-binding protein from Morris hepatoma 5123tc

Eur J Biochem. 1983 Oct 17;136(1):9-17. doi: 10.1111/j.1432-1033.1983.tb07698.x.

Abstract

Oncomodulin is an acidic calcium-binding protein of 108 amino acids which has been detected only in tumors. The complete amino acid sequence of rat oncomodulin has been established, and the N-terminus shown to be N-acetylserine. Homology of the oncomodulin sequence with members of the troponin C superfamily of calcium-binding proteins was demonstrated, and putative calcium-binding domains were located. A further degree of homology was established between oncomodulin and the parvalbumins, including rat parvalbumin. Oncomodulin was therefore considered to be a parvalbumin-like calcium-binding protein.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Calcium-Binding Proteins* / isolation & purification
  • Chemical Phenomena
  • Chemistry
  • Liver Neoplasms, Experimental / analysis*
  • Neoplasm Proteins / isolation & purification*
  • Parvalbumins
  • Peptide Fragments
  • Rats

Substances

  • Calcium-Binding Proteins
  • Neoplasm Proteins
  • Parvalbumins
  • Peptide Fragments
  • oncomodulin