Allergenic properties of naturally occurring cannabinoids

J Pharm Sci. 1983 Aug;72(8):954-5. doi: 10.1002/jps.2600720831.


The guinea pig maximization test was used to determine the potential of seven cannabinoids to produce allergic contact dermatitis. delta 9-Tetrahydrocannabinol and cannabinol were found to be extreme (Grade V) sensitizers. Cannabidiol, delta 8-tetrahydrocannabinol, and cannabichromene were moderate (Grade III) sensitizers. Cannabigerol and cannabinol methyl ether were not sensitizers. Most of the cannabinoids were found to be allergenically cross-reactive. Additionally, it was shown that the presence of a free 1'-hydroxyl group was required for sensitization, but not to elicit a response in sensitive animals.

MeSH terms

  • Allergens*
  • Animals
  • Cannabinoids / immunology*
  • Cross Reactions
  • Female
  • Guinea Pigs


  • Allergens
  • Cannabinoids