Characterization of melanin-concentrating hormone in chum salmon pituitaries

Nature. 1983 Sep 22-28;305(5932):321-3. doi: 10.1038/305321a0.


Many lower vertebrates exhibit colour change in response to the background. A dual hormonal control of colour change by two antagonistic pituitary melanophorotropic hormones was first postulated in amphibia by Hogben and Slome. It is well established that the melanotropins alpha- and beta-MSH are responsible for pigment dispersion in the integumentary melanophore of lower vertebrates and that these molecules are derived from a common precursor protein, proopiocortin, by specific processing within the intermediate lobe. No evidence has been found for an antagonistic hormone in amphibia, although the existence of such a molecule in the pituitary gland of teleost fishes has long been recognized and was termed the melanophore-concentrating hormone by Enami. Early attempts to separate the two hormones proved unsuccessful. Recently, Baker and Ball re-invoked the dual hormone concept, and it has been suggested that a melanin-concentrating hormone (MCH) is synthesized in the hypothalamus of teleosts and stored and released by the neurohyphophysis. We have now isolated a novel peptide from the pituitary of the salmon (Oncorhynchus keta) possessing an antagonistic function to MSH, and we describe here its chemical and biological characteristics.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Hypothalamic Hormones*
  • Melanins / isolation & purification*
  • Melanocyte-Stimulating Hormones / antagonists & inhibitors
  • Melanophores / drug effects*
  • Oligopeptides / analysis
  • Pituitary Gland / analysis*
  • Pituitary Hormones / isolation & purification*
  • Salmon / physiology*


  • Hypothalamic Hormones
  • Melanins
  • Oligopeptides
  • Pituitary Hormones
  • melanin-concentrating hormone
  • Melanocyte-Stimulating Hormones