Neuronal death in the development and aging of the cerebral cortex of the mouse

Neuropathol Appl Neurobiol. Jul-Aug 1983;9(4):297-311. doi: 10.1111/j.1365-2990.1983.tb00116.x.


The numbers of neurons and glial cells in the cerebral cortex of the mouse have been estimated during its whole life-span (5 to 720 days), taking into account both the cellular densities of several areas and the cortical volumes. The results clearly demonstrate that there is a massive neuronal loss in the cerebral cortex during early postnatal development, greater in layers II-IV than in layers V-VI. In contrast, aging is characterized by a discrete neuronal loss in the cerebral cortex, purely restricted to layers II-IV. The number of glial cells increases continuously from 5 to 720 days. We emphasize here the need to obtain volumetric measure together with cellular densities in order to get interpretable quantitative data on cellular death and proliferation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging*
  • Animals
  • Cell Count
  • Cell Survival
  • Cerebral Cortex / cytology
  • Cerebral Cortex / growth & development*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Neurons / cytology
  • Neurons / physiology*