Intact rat liver nuclei catalyze adriamycin irreversible interactions with DNA and nuclear proteins

Toxicol Lett. 1983 Jul;17(3-4):343-8. doi: 10.1016/0378-4274(83)90248-5.

Abstract

Male rat liver intact nuclear preparations are able to metabolize adriamycin to reactive species that irreversibly interact with nuclear DNA and proteins in the presence of reduced NADPH. This process was not inhibited by 1 mM SKF-525A, suggesting that a nuclear monooxygenase enzymatic system was not involved.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Nucleus / drug effects
  • Cell Nucleus / metabolism*
  • DNA / metabolism*
  • Doxorubicin / metabolism
  • Doxorubicin / toxicity*
  • Kinetics
  • Liver / metabolism*
  • Male
  • NADP / metabolism
  • Nucleoproteins / metabolism*
  • Proadifen / pharmacology
  • Rats
  • Rats, Inbred Strains

Substances

  • Nucleoproteins
  • NADP
  • Doxorubicin
  • DNA
  • Proadifen