The effect of a 5-HT antagonist, ketanserin, on blood pressure, the renin-angiotensin system and sympathoadrenal function in normal man

Br J Clin Pharmacol. 1983 Sep;16(3):305-11. doi: 10.1111/j.1365-2125.1983.tb02166.x.

Abstract

The role of endogenous 5-hydroxytryptamine (5-HT) in the control of blood pressure, the renin-angiotensin system and sympatho-adrenal function was investigated in normal man. Ketanserin (a specific 5-HT2 antagonist) administered intravenously caused a small decrease in blood pressure in salt-depleted recumbent subjects. A more marked postural fall in pressure occurred in both sodium-depleted and repleted normal subjects. Plasma active renin concentration and angiotensin II increased after administration of ketanserin, but plasma aldosterone, cortisol and noradrenaline were unchanged. 5-HT may be important in the control of blood pressure in man and specific 5-HT2 receptor antagonists could be a useful new class of antihypertensive agents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Glands / drug effects*
  • Adult
  • Blood Pressure / drug effects*
  • Diet
  • Heart Rate / drug effects
  • Humans
  • Ketanserin
  • Male
  • Phenylephrine
  • Piperidines / pharmacology*
  • Posture
  • Renin-Angiotensin System / drug effects*
  • Serotonin Antagonists / pharmacology*
  • Sympathetic Nervous System / drug effects*
  • Time Factors

Substances

  • Piperidines
  • Serotonin Antagonists
  • Phenylephrine
  • Ketanserin