Terminal degeneration in supraoptic nucleus following subfornical organ lesions: ultrastructural observations in the rat

Brain Res. 1983 Sep 26;275(2):365-8. doi: 10.1016/0006-8993(83)90999-x.


A projection from the subfornical organ (SFO) to the supraoptic nucleus, recently identified in light microscopic studies, was examined at the ultrastructural level following lesions in SFO. After 18-36 h, axon terminal degeneration was identified in axosomatic contacts with supraoptic neurosecretory neurons, and in axodendritic contacts within and around the supraoptic nucleus. These observations confirm a monosynaptic pathway from SFO to supraoptic neurosecretory neurons that may participate in the release of vasopressin following activation of angiotensin II receptors in SFO.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Axons / ultrastructure
  • Kinetics
  • Male
  • Microscopy, Electron
  • Nerve Degeneration*
  • Neurosecretory Systems / physiology*
  • Rats
  • Rats, Inbred Strains
  • Subfornical Organ / physiology*
  • Supraoptic Nucleus / ultrastructure*