A case is presented in which a hyperactive child with secondary enuresis had a dramatic response to both syndromes of methylphenidate therapy. A review of the literature reveals a paucity of controlled studies on the drug treatment of secondary enuresis. Although the deep sleep theory of enuresis is not applicable to primary enuresis, the authors consider its applicability to secondary enuresis, and point out the need for further studies on the treatment of secondary enuresis.