Menstrual delay and dysfunctional uterine bleeding associated with antiprostaglandin therapy for dysmenorrhea

J Reprod Med. 1983 Sep;28(9):592-4.


Antiprostaglandin drugs have been found to provide significant relief from dysmenorrhea. Twelve patients taking ibuprofen or mefenamic acid experienced menstrual delay of several days to two weeks and dysfunctional uterine bleeding. Menstruation returned to normal with the next cycle after the cessation of drug use.

MeSH terms

  • Adult
  • Dysmenorrhea / drug therapy*
  • Female
  • Humans
  • Ibuprofen / adverse effects*
  • Ibuprofen / therapeutic use
  • Mefenamic Acid / adverse effects*
  • Mefenamic Acid / therapeutic use
  • Menstruation Disturbances / chemically induced*
  • Prostaglandin Antagonists / adverse effects*
  • Prostaglandin Antagonists / therapeutic use
  • Uterine Hemorrhage / chemically induced*


  • Prostaglandin Antagonists
  • Mefenamic Acid
  • Ibuprofen