A 54-year-old female was admitted in June 1982, complaining of jaundice and fever of several months' duration. She had undergone cholecystectomy and choledocho-jejunostomy, 22 years and 9 years before, respectively. On admission, PTCD was carried out immediately. It showed marked dilatation, of the common bile duct and stricture of the anastomosed portion. On August 2, she died of jaundice and sepsis. On autopsy, a cystic tumor was found at the common bile duct remnant in the head of the pancreas. It was a tubular adenocarcinoma and invaded the ostium of the choledochojejunostomy. The occurrence of adenocarcinoma may be one of the late complications of choledochojejunostomy.