Changes of the levels of antithrombin III in patients with cerebrovascular diseases

Thromb Res. 1983 Jul 15;31(2):197-202. doi: 10.1016/0049-3848(83)90321-3.


Dynamic fluctuations of biological activities and antigen amounts of antithrombin III (AT-III) in acute cerebrovascular diseases were analyzed and evaluated. (1) AT-III levels assayed by both biological and immunological methods showed a gradual decrease with increasing age, and levels in patients with cerebral thrombosis were lower than those in patients with cerebral hemorrhage. (2) AT-III in cerebral thrombosis decreased slowly after administration of urokinase. After administration of aspirin (acetylsalicylic acid), however, AT-III levels increased presumably due to inhibition of coagulation activities. (3) Both biological activities and antigen amounts of AT-III increased after administration of an AT-III preparation, but the measured value, especially that of biological activity, was dissociated from the expected one, due to changes of the coagulation system after an operation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antithrombin III / analysis*
  • Aspirin / therapeutic use
  • Brain Ischemia / blood
  • Cerebral Hemorrhage / blood
  • Cerebrovascular Disorders / blood*
  • Female
  • Humans
  • Intracranial Embolism and Thrombosis / prevention & control
  • Male
  • Middle Aged
  • Urokinase-Type Plasminogen Activator / therapeutic use


  • Antithrombin III
  • Urokinase-Type Plasminogen Activator
  • Aspirin