The morphogenetic signal of bacteriophage f1

Virology. 1983 Oct 15;130(1):252-6. doi: 10.1016/0042-6822(83)90136-8.


The genome of the single-stranded DNA phage f1 contains an intergenic region (IG), 508-nucleotides long, that does not code for any known protein. By use of a system of chimeric plasmids haboring different f1 fragments, we had previously shown that this region contains, in addition to the f1 'functional origin' of DNA replication, a signal of less than 300 nucleotides required for efficient morphogenesis to occur ('morphogenetic signal'). In the present study, we have localized this signal to within a sequence of less that 60 nucleotides of almost perfect palindromic symmetry at the genet IV/IG border. We also present data indicating that the morphogenetic signal is not necessary for the synthesis of single-stranded DNA, but is necessary only at some later step during virion maturation.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Coliphages / genetics
  • Coliphages / growth & development*
  • Coliphages / metabolism
  • DNA, Single-Stranded / biosynthesis
  • DNA, Viral / biosynthesis
  • Genes, Viral*
  • Morphogenesis
  • Plasmids


  • DNA, Single-Stranded
  • DNA, Viral

Associated data

  • GENBANK/K00967