We have experienced 540 cases with Kawasaki disease over the past 10 years. Six of them (1.1%) had neurological complications with clinical manifestation. Two infants had central nervous system involvement with remarkable changes of cerebrum on CT scan during an acute stage, and these findings disappeared completely within six months. One of these two patients showed no abnormal changes on cerebral angiography. The other four infants had lower motor neuron facial palsy of acute onset and improved within two months.